Scientific paper on metabolic engineering for sustainable chemical production

A new study, published by our colleagues at Universitat Autònoma de Barcelona, showcases VIVALDI's innovative research on metabolic engineering for sustainable chemical production.

The study focuses on Komagataella phaffii, a methylotrophic yeast, and its potential to convert methanol—derived from CO₂ reduction—into 3-hydroxypropionic acid (3-HP), a key building block for biobased materials. By applying advanced metabolic engineering strategies, the researchers Sílvia Àvila Cabré, Joan Albiol and Pau Ferrer significantly improved 3-HP titers, yields, and productivity, bringing us closer to commercially viable, sustainable production.

Why does this matter?
- Reduces reliance on fossil fuels
- Supports a circular carbon economy
- Enhances the efficiency of bioproduction

The findings highlight the crucial role of lactate transporters in optimizing 3-HP export, even at lower pH conditions. This study paves the way for scalable, industrial applications and is a testament to how the VIVALDI project is driving innovation in sustainable biomanufacturing.

The full study can be read in Open Access here.